Tranmere boss Les Parry is confident that Marlon Broomes and Paul McLaren will be passed fit for the home clash with Leeds.
Defender Broomes is nursing a toe injury sustained in Saturday's home win over Southampton and midfielder McLaren is suffering from illness and was withdrawn in the closing stages at the weekend.
However, striker Bas Savage is suffering from a chest infection and could miss out, while influential defender Ian Goodison will play on despite an ankle problem.
Parry said: "Ian is not going to be 100% now until the end of the season when we're able to rest it and do some further investigation to see if we can do anything in the close season to alleviate the long term problem.
"It's just going to be a matter of managing it."
Leeds manager Simon Grayson could be without Richard Naylor, Andrew Hughes, Shane Lowry and Mike Grella.
Centre-half Naylor missed the home draw with Brentford last weekend due to a thigh injury sustained the previous week at Huddersfield, while fellow defender Hughes was withdrawn shortly after half-time on Saturday because of illness.
Full-back Lowry, on loan from Aston Villa, also missed out against Brentford due to a knee problem, while American striker Grella is struggling with an unspecified injury.
Lubo Michalik will continue alongside Patrick Kisnorbo at the heart of defence if Naylor fails to make it, while Bradley Johnson could be recalled to cover for either Hughes or Lowry.
Veteran striker Paul Dickov made his first Leeds appearance as a late substitute against Brentford and will be hoping to play a bigger part at Tranmere as Grayson's side look to close the gap on leaders Norwich to four points.
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