Everton v Liverpool
Rivals Liverpool and Everton clash at Wembley Stadium for the FA Cup semi-final on Saturday afternoon in a huge Merseyside derby for both clubs.
After what has been a disappointing season in the league, Liverpool captain Steven Gerrard admits his side are desperate to reach the final.
With Pepe Reina and Alexander Doni both suspended, third choice goalkeeper Brad Jones will start after a solid performance at Blackburn.
Everton meanwhile are in fine form, enjoying a great run in the league. Nikica Jelavic will be looking to continue his impressive start at the club.
Norwich City v Manchester City
In the Premier League, Manchester City travel to Norwich knowing they can close the gap on rivals United to just two points with a win.
Mario Balotelli serves the second game of a three match ban, with Carlos Tevez and Sergio Aguero expected to continue in attack.
West Bromich Albion v Queens Park Rangers
QPR are also in action, looking to build upon last weekend's win over Swansea as they aim to haul themselves further away from danger.
Sunderland v Wolves/Swansea v Blackburn
Elsewhere, Sunderland face bottom of the table Wolves with relegation all but confirmed for Terry Connor's side, while Swansea face Blackburn.