Oldham will face an FA Cup clash at Liverpool after Chris Taylor's goal secured a 1-0 win against Southend in their second-round replay.
The Shrimpers paid the price for Bilel Mohsni's first-half red card as the home side went on to dominate with a composed display.
Oldham made the breakthrough when James Wesolowski's lay-off set up Taylor to smash home from 10 yards after 58 minutes.
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